CLINICAL, MORPHOLOGICAL, AND CYTOGENETIC CHARACTERISTICS OF PATIENTS WITH LYMPHOID MALIGNANCIES CHARACTERIZED BY BOTH T(14-18)(Q32-Q21) AND T(8-14)(Q24-Q32) OR T(8-22)(Q24-Q11)

被引：116

作者：

THANGAVELU, M ^{[1
]}

OLOPADE, O ^{[1
]}

BECKMAN, E ^{[1
]}

VARDIMAN, JW ^{[1
]}

LARSON, RA ^{[1
]}

MCKEITHAN, TW ^{[1
]}

LEBEAU, MM ^{[1
]}

ROWLEY, JD ^{[1
]}

机构：

[1] UNIV CHICAGO, DEPT PATHOL, CHICAGO, IL 60637 USA

来源：

GENES CHROMOSOMES & CANCER | 1990年 / 2卷 / 02期

关键词：

D O I：

10.1002/gcc.2870020211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Six patients with an aggressive leukemia/lymphoma disorder had a t(14;18) as well as either a t(8;14) (three patients) or a t(8;22) (three patients). Leukemia cells from all three patients with the t(8;22) had a mature B cell phenotype (Smlg+ and TdT−), whereas two of three patients with the t(8;14) had a pre‐B phenotype and were Smlg−. None of the patients with the t(8;22) had a prior history of follicular lymphoma, whereas two of the three patients with the t(8;14) had had a follicular lymphoma. The clinical, cytogenetic, and morphologic characteristics of these six patients along with eight previously reported cases with both the t(14;18), and the t(8;14), the t(8;22) or the t(2;8) are discussed. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：147 / 158

页数：12

共 32 条

[1] CORRELATION OF SECONDARY CYTOGENETIC ABNORMALITIES WITH HISTOLOGIC APPEARANCE IN NON-HODGKINS LYMPHOMAS BEARING T(14, 18)(Q32, Q21) [J].