IMMUNOMODULATION BY COCAINE - A NEUROENDOCRINE MEDIATED RESPONSE

被引：80

作者：

WATZL, B

WATSON, RR

机构：

[1] Department of Family, Community Medicine University, Arizona Health Sciences Center Tucson

来源：

LIFE SCIENCES | 1990年 / 46卷 / 19期

关键词：

D O I：

10.1016/0024-3205(90)90331-K

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cocaine acts directly on lymphoid cells and indirectly modulates the immune response by affecting the level of neuroendocrine hormones. In vitro, very high concentrations of cocaine inhibit different immune responses, while plasma levels following cocaine use have no effect. The results of the few published in vivo studies are contradictory, showing stimulatory, suppressive or no effect on lymphoid cells. The indirect effects of cocaine on the immune system could be mediated by ACTH, beta-endorphin and corticosterone. Anorectic effect associated with nutritional deficiencies of drug users could additionally affect the immune response by cocaine. © 1990.

引用

收藏

页码：1319 / 1329

页数：11

相关论文

共 67 条

[1] CHOICE BEHAVIOR IN RHESUS-MONKEYS - COCAINE VERSUS FOOD [J].

AIGNER, TG ;

BALSTER, RL .

SCIENCE, 1978, 201 (4355) :534-535

[2] ECGONINE METHYL-ESTER, A MAJOR METABOLITE OF COCAINE [J].

AMBRE, JJ ;

RUO, TI ;

SMITH, GL ;

BACKES, D ;

SMITH, CM .

JOURNAL OF ANALYTICAL TOXICOLOGY, 1982, 6 (01) :26-29

[3]

[Anonymous], FRONT NEUROENDOCRIN

[4]

BAGASRA O, 1989, CLIN EXP IMMUNOL, V77, P289

[5] COCAINE AND D-AMPHETAMINE INDUCE CHANGES IN CENTRAL BETA-ADRENOCEPTOR SENSITIVITY - EFFECTS OF ACUTE AND CHRONIC DRUG-TREATMENT [J].

BANERJEE, SP ;

SHARMA, VK ;

KUNGCHEUNG, LS ;

CHANDA, SK ;

RIGGI, SJ .

BRAIN RESEARCH, 1979, 175 (01) :119-130

[6] COMPARATIVE BEHAVIORAL PROFILE OF COCAINE AND NORCOCAINE IN RATS AND MONKEYS [J].

BEDFORD, JA ;

BORNE, RF ;

WILSON, MC .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1980, 13 (01) :69-75

[7] MOLECULAR CHARACTERIZATION OF A CORTICOTROPIN (ACTH) RECEPTOR [J].

BOST, KL ;

BLALOCK, JE .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1986, 44 (01) :1-9

[8] TOXICITY ASSOCIATED WITH LONG-TERM INTRAVENOUS HEROIN AND COCAINE SELF-ADMINISTRATION IN THE RAT [J].

BOZARTH, MA ;

WISE, RA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1985, 254 (01) :81-83

[9] EFFECT OF ERYTHROXYLUM-COCA, COCAINE AND ECGONINE METHYL-ESTER AS DIETARY-SUPPLEMENTS ON ENERGY-METABOLISM IN THE RAT [J].

BURCZYNSKI, FJ ;

BONI, RL ;

ERICKSON, J ;

VITTI, TG .

JOURNAL OF ETHNOPHARMACOLOGY, 1986, 16 (2-3) :153-166

[10] THE ROLE OF FOOD-DEPRIVATION IN THE MAINTENANCE AND REINSTATEMENT OF COCAINE-SEEKING BEHAVIOR IN RATS [J].

CARROLL, ME .

DRUG AND ALCOHOL DEPENDENCE, 1985, 16 (02) :95-109

← 1 2 3 4 5 6 7 →