TOLEROGENICITY OF THYMIC EPITHELIUM

被引：74

作者：

WEBB, SR

SPRENT, J

机构：

[1] Department of Immunology, Research Institute of Scripps Clinic, La Jolla

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 11期

关键词：

D O I：

10.1002/eji.1830201127

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To attempt to resolve the controversy on the role of thymic epithelial cells (TEC) in tolerance induction, athymic mice were grafted with allogeneic day‐14 fetal thymuses treated with deoxyguanosine in vitro. The data indicate that the tolerogenicity of TEC varies considerably according to the antigen and the subpopulation of T cells studied. For cytotoxic CD8+ cells responding to H‐2 class I antigens, TEC induce minimal tolerance. For proliferative responses of CD4+ cells, by contrast, TEC induce significant tolerance to H‐2 class II antigens but no detectable tolerance to Mls3 antigens. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：2525 / 2528

页数：4

共 15 条

[1]

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