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ISOLATION AND CHARACTERIZATION OF A YEAST CHROMOSOMAL REPLICATOR

被引：600
作者：
STINCHCOMB, DT
STRUHL, K
DAVIS, RW
机构：
[1] Department of Biochemistry, Stanford University, School of Medicine, Stanford
来源：
NATURE | 1979年 / 282卷 / 5734期
关键词：
D O I：
10.1038/282039a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A yeast DNA sequence that behaves as a chromosomal replicator, ars1 (autonomously replicating sequence), has been isolated. On transformation, ars1 allows autonomous replication of all co-linear DNA. The replicator can integrate into other replication units and can function in multimeric form. The 850-base pair ars1 element has no detectable homology to other yeast sequences. Such replicator-containing plasmids can be used for the isolation of DNA sequences in yeast cells as well as for the study of chromosomal DNA replication. © 1979 Nature Publishing Group.
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页码：39 / 43
页数：5
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