NEUTRAL ENDOPEPTIDASE INHIBITORS AND ATRIAL-NATRIURETIC-PEPTIDE

被引：5

作者：

ACHILIHU, G ^{[1
]}

FRISHMAN, WH ^{[1
]}

LANDAU, A ^{[1
]}

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT MED,BRONX,NY 10461

来源：

JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 08期

关键词：

D O I：

10.1002/j.1552-4604.1991.tb03773.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A limited number of ectoenzymes appear to be involved in the inactivation of circulating-regulatory peptides. Neutral endopeptidase 24.11, a metallopeptidase, is known to inactivate atrial natriuretic peptide (ANP), a substance with diuretic, natriuretic, and vasodilatory effects. Synthetic inhibitors of endopeptidase 24.11, which can prolong the activity of ANP, are currently available. These agents are being evaluated as possible innovative therapies for patients with hypertension and congestive heart failure.

引用

页码：758 / 762

页数：5

共 51 条

[1] ALABASTER C T, 1989, Journal of the American College of Cardiology, V13, p75A
[2] BARCLAY PL, 1989, J AM COLL CARDIOL, V13, pP824
[3] BERNARD PR, 1990, TRENDS PHARMACOL SCI, V2, P245
[4] DEGRADATION OF ATRIAL NATRIURETIC PEPTIDES BY AN ENZYME IN RAT-KIDNEY RESEMBLING NEUTRAL ENDOPEPTIDASE 24.11
BERTRAND, P
DOBLE, A
[J]. BIOCHEMICAL PHARMACOLOGY, 1988, 37 (20) : 3817 - 3821
[5] DIURETIC AND NATRIURETIC RESPONSES IN RATS TREATED WITH ENKEPHALINASE INHIBITORS
BRALET, J
MOSSIAT, C
LECOMTE, JM
CHARPENTIER, S
GROS, C
SCHWARTZ, JC
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 179 (1-2) : 57 - 64
[6] CARDIORENAL ACTIONS OF NEUTRAL ENDOPEPTIDASE INHIBITION IN EXPERIMENTAL CONGESTIVE HEART-FAILURE
CAVERO, PG
MARGULIES, KB
WINAVER, J
SEYMOUR, AA
DELANEY, NG
BURNETT, JC
[J]. CIRCULATION, 1990, 82 (01) : 196 - 201
[7] CHIPKIN RE, 1986, J PHARMACOL EXP THER, V237, P937
[8] CROZIER IG, 1986, LANCET, V2, P1242
[9] PROLONGED LOW-DOSE INFUSION OF ATRIAL NATRIURETIC FACTOR IN ESSENTIAL-HYPERTENSION
CUSSON, JR
THIBAULT, G
CANTIN, M
LAROCHELLE, P
[J]. CLINICAL AND EXPERIMENTAL HYPERTENSION PART A-THEORY AND PRACTICE, 1990, 12 (01) : 111 - 135
[10] UK-69,578, A NOVEL INHIBITOR OF EC-342411 WHICH INCREASES ENDOGENOUS ANF LEVELS AND IS NATRIURETIC AND DIURETIC
DANILEWICZ, JC
BARCLAY, PL
BARNISH, IT
BROWN, D
CAMPBELL, SF
JAMES, K
SAMUELS, GMR
TERRETT, NK
WYTHES, MJ
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 164 (01) : 58 - 65

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