ALZHEIMERS-DISEASE - THE RELATIONSHIP BETWEEN THE DENSITY OF SENILE PLAQUES, NEUROFIBRILLARY TANGLES AND A4 PROTEIN IN HUMAN PATIENTS

被引：27

作者：

ARMSTRONG, RA ^{[1
]}

MYERS, D ^{[1
]}

SMITH, CUM ^{[1
]}

CAIRNS, N ^{[1
]}

LUTHERT, PJ ^{[1
]}

机构：

[1] INST PSYCHIAT,DEPT NEUROPATHOL,MRC,ALZHEIMERS DIS BRAIN BANK,LONDON SE5 8AF,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1991年 / 123卷 / 02期

关键词：

ALZHEIMERS DISEASE; SENILE PLAQUE; NEUROFIBRILLARY TANGLE; A4; DEPOSIT;

D O I：

10.1016/0304-3940(91)90915-G

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The numerical density of senile plaques (SP) and neurofibrillary tangles (NFT) as revealed by the Glees silver method was compared with SP and NFT revealed by the Gallyas method and with amyloid (A4) deposits in immunostained sections in 6 elderly cases of Alzheimer's disease. The density of NFT was generally greater and A4 lower in tissue from hippocampus compared with the neocortex suggesting that A4 deposition was less important than the degree of paired helical filament (PHF) related damage in the hippocampus. The density of Glees SP was positively correlated Gallyas SP weakly correlated with A4 deposit number. A stepwise multiple regression analysis which included A4 deposit and Gallyas SP density and accounted for 54% of the variation in Glees SP density. Hence different populations of SP were revealed by the different staining methods. The results suggested that the Glees method may stain a population of SP in a region of cortex where both amyloid deposition and neurofibrillary changes have occurred.

引用

页码：141 / 143

页数：3

共 16 条

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