DOWN-REGULATION OF INTERLEUKIN-2 RECEPTOR EXPRESSION ON NATURAL-KILLER-CELLS LARGE GRANULAR LYMPHOCYTES BY INTERLEUKIN-4

被引:4
作者
BOSSE, D [1 ]
ADES, E [1 ]
机构
[1] CTR DIS CONTROL,CTR INFECT DIS,SCI RESOURCES PROGRAM,BIOL PROD BRANCH,BLDG 13207 D34,ATLANTA,GA 30333
关键词
INTERLEUKIN-4; NATURAL KILLER CELLS; INTERLEUKIN-2 RECEPTOR INHIBITION; LARGE GRANULAR LYMPHOCYTES;
D O I
10.1159/000163701
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
It has recently been demonstrated that IL-4 inhibits IL-2 receptor expression on T cells. Studies have also shown that IL-4 can inhibit IL-2-induced natural killer cell (NK) cytotoxicity, and that IL-4 in combination with IL-2 and large granular lymphocyte (NK/LGL) cells suppresses Ig synthesis. Therefore, we examine whether IL-2 receptor expression on NK/LGL cells is affected with or without IL-4, using fluorescent receptor analysis. Our results demonstrate that IL-4 inhibits/down-regulates the expression of IL-2 receptors on either phytohemagglutinin or IL-2-stimulated NK/LGL cells.
引用
收藏
页码:72 / 75
页数:4
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