DISPOSITION OF ENANTIOMERS OF SULPIRIDE IN HUMANS AND RATS

被引：10

作者：

KAMIZONO, A

INOTSUME, N

FUKUSHIMA, S

NAKANO, M

OKAMOTO, Y

机构：

[1] KUMAMOTO UNIV HOSP,DEPT PHARMACEUT SERV,1-1-1 HONJO,KUMAMOTO 860,JAPAN

[2] NAGOYA UNIV,FAC ENGN,CHIKUSA KU,NAGOYA 46401,JAPAN

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1993年 / 14卷 / 06期

关键词：

SULPIRIDE; ENANTIOMER; STEREOSELECTIVE DISPOSITION; HUMAN; RAT;

D O I：

10.1002/bdd.2510140603

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pharmacokinetics of sulpiride enantiomers after intravenous administration of (+/-)-, (+)-, and (-)-sulpiride was examined in humans and rats. Pharmacokinetic profiles were similar in (+)- and (-)-enantiomers after intravenous administration of (+/-)-sulpiride. Metabolic inversion at a chiral centre was not observed after intravenous administration of each enantiomer in rats.

引用

页码：475 / 481

页数：7

共 19 条

[1]

ABAS A, 1987, J PHARMACOL EXP THER, V240, P637

[2]

AGANATI LF, 1981, APOMORPHINE OTHER DO, P251

[3] POSSIBLE MIXED AGONIST-ANTAGONIST ACTIVITY OF D-SULPIRIDE AT DOPAMINE RECEPTOR LEVEL IN MAN [J].