COMMON STRUCTURAL PATTERNS OF CYTOKINE OUTER SURFACES

被引：7

作者：

DENESYUK, AI ^{[1
]}

ZAVYALOV, VP ^{[1
]}

KORPELA, T ^{[1
]}

机构：

[1] UNIV TURKU,FINNISH RUSSIAN JOINT BIOTECHNOL LAB,SF-20520 TURKU,FINLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 201卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.1858

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Schemes of the four-helix bundle surfaces of interleukin-2, -4, -5, granulacyte/macrophage-, granulocyte-, macrophage-colony-stimulating factor, interferon-beta, -gamma and growth hormone were designed. Ah cytokines appeared to have the structurally similar ''holes'' on the surfaces. They were suggested to serve as a part of the main receptor-binding sites. (C) 1994 Academic Press, Inc.

引用

页码：1396 / 1400

页数：5

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