INVOLVEMENT OF THE TYROSINASE GENE IN THE DEPOSITION OF CARDIAC LIPOFUSCIN IN MICE - ASSOCIATION WITH AORTIC FATTY STREAK DEVELOPMENT

被引：15

作者：

QIAO, JH

WELCH, CL

XIE, PZ

FISHBEIN, MC

LUSIS, AJ

机构：

[1] UNIV CALIF LOS ANGELES,DEPT MED,DIV CARDIOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,INST MOLEC BIOL,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,DEPT PATHOL,LOS ANGELES,CA 90024

[5] DEPT CEDARS SINAI MED CTR,LOS ANGELES,CA 90048

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 92卷 / 05期

关键词：

ATHEROSCLEROSIS; LIPID OXIDATION; ALBINO LOCUS; MELANIN; INFLAMMATION;

D O I：

10.1172/JCI116844

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lipofuscin pigment, a terminal oxidation product, accumulates within cells during the normal aging process and under certain pathological conditions. We have analyzed a genetic cross between two inbred mouse strains, BALB/cJ and a subline of C57BL/6J, which differ in lipofuscin deposition. A comparison of the segregation pattern of cardiac lipofuscin with the albino locus (c) on mouse chromosome 7 revealed complete concordance. Analysis of spontaneous mutants of the tyrosinase gene, encoded by the albino locus, confirmed that the tyrosinase gene itself controls lipofuscin formation. Genetic analysis of other strains indicated that one or more additional genes can contribute to the inheritance of lipofuscin. We also present evidence for an association between cardiac lipofuscin deposition and aortic fatty streak development in the mouse.

引用

页码：2386 / 2393

页数：8

共 47 条

[1] LYSOSOMAL MUTATIONS INHIBIT LIPOFUSCINOSIS OF THE SPLEEN IN C57BL MICE [J].