BRONCHODILATORY EFFECTS OF IPRATROPIUM BROMIDE IN PATIENTS WITH TETRAPLEGIA

被引：34

作者：

ALMENOFF, PL

ALEXANDER, LR

SPUNGEN, AM

LESSER, MD

BAUMAN, WA

机构：

[1] Department of Medicine, Mount Sinai School of Medicine, New York

[2] Rehabilitation Medicine, Mount Sinai School of Medicine, New York

[3] Spinal Cord Damage Research Center, Bronx, NY

[4] Spinal Cord Injury Service, Bronx, NY

[5] Pulmonary/Critical Care Medicine, Veterans Affairs Medical Center, Bronx, NY

来源：

PARAPLEGIA | 1995年 / 33卷 / 05期

关键词：

BRONCHIAL OBSTRUCTION; PULMONARY; LUNGS; SPINAL CORD INJURY; TETRAPLEGIA; ANTICHOLINERGIC AGENTS; IPRATROPIUM;

D O I：

10.1038/sc.1995.62

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Airway hyperresponsiveness was recently described in patients with chronic cervical spinal cord injury (tetraplegia). The response was attributed to unopposed cholinergic bronchoconstrictor activity due to loss of sympathetic innervation of the airway. To determine if the administration of a cholinergic antagonist alters resting airway tone in these patients, ipratropium bromide (72 mu g) was administered by aerosol to 25 tetraplegic patients. We found that 12 of 25 patients (48%) had significant improvement (defined as greater than or equal to 12%) in forced expired volume in 1 s (FEV(1)) and/or forced vital capacity (FVC). A significant correlation between airway responsiveness and complaints of dyspnea at rest, completeness of injury (sensory), or smoking history was not found. These findings of improved airflow after the use of an anticholinergic bronchodilator agent provides further evidence that transection of the cervical cord results in unopposed parasympathetic activity and a resultant increase in resting airway tone.

引用

页码：274 / 277

页数：4

共 25 条

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