LYSERGIC ACID DIETHYLAMIDE - ROLE IN CONVERSION OF PLASMA TRYPTOPHAN TO BRAIN SEROTONIN (5-HYDROXYTRYPTAMINE)

被引：68

作者：

LIN, RC

NGAI, SH

COSTA, E

机构：

[1] Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York

[2] Laboratory of Preclinical Pharmacology, National Institute of Mental Health, St. Elizabeths Hospital, Washington

来源：

SCIENCE | 1969年 / 166卷 / 3902期

关键词：

D O I：

10.1126/science.166.3902.237

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Injections of D-lysergic acid diethylamide decrease the turnover rate of 5-hydroxytryptamine of rat brain, as measured from the conversion of 14C-tryptophan into 14C-5-hydroxytryptamine. The 2-bromolysergic acid diethylamide given in doses fivefold greater than those of lysergic acid diethylamide fails to change the rate of 14C-tryptophan conversion into 14C-5-hydroxytryptamine. The effect of D-lysergic acid diethylamide is discussed with regard to its action on brain serotonergic neurons and its psychotomimetic effects.

引用

页码：237 / &

共 16 条

[1] LYSERGIC ACID DIETHYLAMIDE - SENSITIVE NEURONAL UNITS IN MIDBRAIN RAPHE [J].