INTRINSIC DISSOLUTION RATES OF TABLET FILLER-BINDERS AND THEIR INFLUENCE ON THE DISSOLUTION OF DRUGS FROM TABLET FORMULATIONS

被引：13

作者：

KOPARKAR, AD ^{[1
]}

AUGSBURGER, LL ^{[1
]}

SHANGRAW, RF ^{[1
]}

机构：

[1] UNIV MARYLAND,SCH PHARM,BALTIMORE,MD 21201

来源：

PHARMACEUTICAL RESEARCH | 1990年 / 7卷 / 01期

关键词：

calcium salt; drug dissolution; intrinsic dissolution rate; lactose; rotating disk method; tablet filler;

D O I：

10.1023/A:1015895827989

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intrinsic dissolution rates were determined for different grades of commonly used calcium salt fillers and lactose. Typical tablet formulations of low-dose drugs were studied to determine the influence of this property on drug dissolution. © 1990, Plenum Publishing Corporation. All rights reserved.

引用

页码：80 / 86

页数：7