CIRCADIAN VARIATION IN THE ONSET OF ACUTE CEREBRAL-ISCHEMIA - ETHIOPATHOGENETIC CORRELATES IN 80 PATIENTS GIVEN ANGIOGRAPHY

被引：22

作者：

TONI, D

ARGENTINO, C

GENTILE, M

SACCHETTI, ML

GIRMENIA, F

MILLEFIORINI, E

FIESCHI, C

机构：

[1] Department of Neurological Sciences, University, La Sapienza, Rome

来源：

CHRONOBIOLOGY INTERNATIONAL | 1991年 / 8卷 / 05期

关键词：

CEREBRAL ISCHEMIA; CEREBROVASCULAR DISORDERS; CIRCADIAN RHYTHM ANGIOGRAPHY; PATHOPHYSIOLOGY;

D O I：

10.3109/07420529109059168

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a continuous series of 80 acute ischemic hemispheric strokes, the onset of symptoms was between 6:01 a.m. and noon in 45% of cases, between noon and 6:00 p.m. in 22.5%, between 6:01 p.m. and midnight in 31.25%, and between midnight and 6:00 a.m. in 1.25% (p < 0.0001). By means of angiography and computerized tomography, and by detection of arterial and cardiac sources of emboli, four stroke subtypes were identified. Embolic and thrombotic strokes had their most frequent onset between 6:01 a.m. and noon (45% and 71 %, respectively), whereas strokes of unknown origin and lacunar strokes were randomly distributed between 6:01 p.m. and midnight. The morning activation of the catecholaminergic system can account for this pattern of circadian onset of ischemic stroke.

引用

页码：321 / 326

页数：6

共 16 条

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