SYNTHESIS OF THE TRICYCLIC NUCLEUS OF THE ALKALOID STEMOFOLINE - X-RAY CRYSTAL-STRUCTURE OF (4RS,5RS,7SR,10RS)-10-BUTYL-5-HYDROXY-1-AZATRICYCLO[5.3.0.0(4,10)]DECAN-2-ONE

被引:34
作者
BEDDOES, RL [1 ]
DAVIES, MPH [1 ]
THOMAS, EJ [1 ]
机构
[1] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND
关键词
D O I
10.1039/c39920000538
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The tricyclic lactams 20 and 21 have been synthesized using iminium ion cyclisations and formation of the third ring via halogen metal exchange; oxidation of the lactam 22 using lead(IV) acetate gave the tetracyclic ether 27 regioselectively.
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页码:538 / 540
页数:3
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