ON THE RATIONAL DESIGN OF RENIN INHIBITORS - X-RAY STUDIES OF ASPARTIC PROTEINASES COMPLEXED WITH TRANSITION-STATE ANALOGS

被引：112

作者：

BLUNDELL, TL ^{[1
]}

COOPER, J ^{[1
]}

FOUNDLING, SI ^{[1
]}

JONES, DM ^{[1
]}

ATRASH, B ^{[1
]}

SZELKE, M ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH,DEPT CHEM PATHOL,LONDON W12 0HS,ENGLAND

来源：

关键词：

D O I：

10.1021/bi00392a001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：5585 / 5590

页数：6

共 52 条

[1] 3-DIMENSIONAL STRUCTURE OF HUMAN RENIN
AKAHANE, K
UMEYAMA, H
NAKAGAWA, S
MORIGUCHI, I
HIROSE, S
IIZUKA, K
MURAKAMI, K
[J]. HYPERTENSION, 1985, 7 (01) : 3 - 12
[2] ANDREEVA NS, 1984, J BIOL CHEM, V259, P1353
[3] ARROWSMITH RJ, 1986, J CHEM SOC CHEM COMM, V10, P755
[4] 3-DIMENSIONAL STRUCTURE, SPECIFICITY AND CATALYTIC MECHANISM OF RENIN
BLUNDELL, T
SIBANDA, BL
PEARL, L
[J]. NATURE, 1983, 304 (5923) : 273 - 275
[5] BLUNDELL TL, 1985, ASPARTIC PROTEINASES, P151
[6] NOVEL RENIN INHIBITORS CONTAINING THE AMINO-ACID STATINE
BOGER, J
LOHR, NS
ULM, EH
POE, M
BLAINE, EH
FANELLI, GM
LIN, TY
PAYNE, LS
SCHORN, TW
LAMONT, BI
VASSIL, TC
STABILITO, II
VEBER, DF
RICH, DH
BOPARI, AS
[J]. NATURE, 1983, 303 (5912) : 81 - 84
[7] Boger J., 1985, ASPARTIC PROTEINASES, P401
[8] 3-DIMENSIONAL STRUCTURE OF THE COMPLEX OF THE RHIZOPUS-CHINENSIS CARBOXYL PROTEINASE AND PEPSTATIN AT 2.5-A RESOLUTION
BOTT, R
SUBRAMANIAN, E
DAVIES, DR
[J]. BIOCHEMISTRY, 1982, 21 (26) : 6956 - 6962
[9] BOTT R, 1983, 8TH P AM PEPT S ROCK, P531
[10] CONSTRUCTION OF A MODEL FOR THE 3-DIMENSIONAL STRUCTURE OF HUMAN RENAL RENIN
CARLSON, W
KARPLUS, M
HABER, E
[J]. HYPERTENSION, 1985, 7 (01) : 13 - 26