INTESTINAL ABSORPTION OF HEPARIN FACILITATED BY SULFATED OR SULFONATED SURFACTANTS

被引：28

作者：

ENGEL, RH

RIGGI, SJ

机构：

[1] Department of Metabolic Chemotherapy, Lederle Laboratories, American Cyanamid Company, New York, 10965, Pearl River

[2] Battelle Memorial Institute, Duxbury, Massachusetts

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 06期

关键词：

Heparin; intestinal absorption—surfactant effect; Intraduodenal administration—heparin; surfactants; Surfactants; sulfated; sulfonated—heparin absorption; Turbidimetric analysis—spectrophotometer;

D O I：

10.1002/jps.2600580612

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The intraduodenal administration of heparin in combination with selected sulfated or sulfonated surfactants results in the appearance of circulating clearing factor activity (lipoprotein lipase). High levels occur within 30 min., indicating rapid absorption of heparin. The characteristics of absorption have been studied using a factorial statistical design. Both sodium lauryl sulfate and dioctyl sodium sulfosuccinate show a simple dose response relationship for surfactant and heparin, while an alkyl aryl sulfate and sodium taurocholate reveal more complex characteristics not easily resolved. The administration of heparin and dioctyl sodium sulfosuccinate in enteric‐coated capsules to the dog results in the appearance of significant clearing factor activity 3 hr. after dosing. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：706 / &

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