INFLUENCE OF NET CHARGE ON THE AGGREGATION AND SOLUBILITY BEHAVIOR OF AMPHOTERICIN-B AND ITS DERIVATIVES IN AQUEOUS-MEDIA

被引：74

作者：

MAZERSKI, J

GRZYBOWSKA, J

BOROWSKI, E

机构：

[1] Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdańsk, Gdańsk

来源：

EUROPEAN BIOPHYSICS JOURNAL | 1990年 / 18卷 / 03期

关键词：

aggregation; Amphotericin B; aqueous media; mathematical model; solubility;

D O I：

10.1007/BF02427375

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The poor solubility of polyene antibiotics in aqueous media limits their application in the therapy of systemic fungal infections. In the present paper we have demonstrated that the ionic state (net electrical charge) of the antibiotic molecule is an important factor in determining the aggregation and solubility properties of amphotericin B and its derivatives. A multi-step model of polyene self-association in aqueous media has been proposed as an explanation for the fact that some major differences are observed when aggregation is monitored by different techniques. © 1990 Springer-Verlag.

引用

页码：159 / 164

页数：6

共 16 条

[1] INTERACTION BETWEEN PHOSPHOLIPID-BILAYER MEMBRANES AND THE POLYENE ANTIBIOTIC AMPHOTERICIN-B - LIPID STATE AND CHOLESTEROL CONTENT DEPENDENCE [J].