SYNTHESIS OF 7-AMINO-1,4-DIHYDRO-4-OXO-6-(TRIFLUOROMETHYL)-1,8-NAPHTHYRIDINES - THE USE OF METHYLIDENEMALONATE AS AN ACTIVATING GROUP AND A SULFUR ASSISTED CYCLIZATION

被引：8

作者：

BRIDGES, AJ

SANCHEZ, JP

机构：

[1] Department of Chemistry, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan, 48105

[2] Eisai Research Institute, Andover, Massachusetts, 01810

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 06期

关键词：

D O I：

10.1002/jhet.5570270602

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2,6‐Dichloro‐3‐(trifluoromethyl)pyridine 3 was used to develop a six‐step preparation of 7‐amino‐4‐oxo‐6‐(trifluoromethyl)naphthyridines. The CF3 group deactivated the pyridine ring towards both nucleophiles and electrophiles. A new reagent for pyridone annulation, the aminomethylidenemalonate anion, is described, along with several strategies to manipulate the electron density of substituted pyridines. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：1527 / 1536

页数：10

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