DEVELOPMENTAL REGULATION OF INSULIN-LIKE GROWTH FACTOR-II MANNOSE 6-PHOSPHATE RECEPTOR MESSENGER-RNA IN THE RAT

被引：29

作者：

BALLESTEROS, M ^{[1
]}

SCOTT, CD ^{[1
]}

BAXTER, RC ^{[1
]}

机构：

[1] ROYAL PRINCE ALFRED HOSP,DEPT ENDOCRINOL,CAMPERDOWN,NSW 2050,AUSTRALIA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 02期

关键词：

D O I：

10.1016/0006-291X(90)90741-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study examined levels of insulin-like growth factor-II/mannose 6-phosphate receptor ( IGF-II M6PR) mRNA in tissues of rats at different stages of growth. Northern blot analysis of total RNA from tissues of rats aged 2, 9, 21 and 42 days and from 21 day fetal rats was carried out using a cDNA probe to the IGF-II M6PR. Northern blots showed this probe hybridized to a single 9kb band in all tissues tested. Highest hybridization signals were detected in fetal and neonatal tissues with levels rapidly decreasing after birth. For all age groups tested the highest signal was obtained with heart followed by muscle, lung, and kidney, with liver and brain showing lower levels of message. These results indicate that IGF-II M6PR mRNA is developmentally regulated, and suggest a role for the IGF-II M6PR in fetal and neonatal growth. © 1990.

引用

页码：775 / 779

页数：5

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