CHRONIC EFFECTS OF GAMMA-INTERFERON ON QUINOLINIC ACID AND INDOLEAMINE-2,3-DIOXYGENASE IN BRAIN OF C57BL6 MICE

被引：76

作者：

SAITO, K ^{[1
]}

MARKEY, SP ^{[1
]}

HEYES, MP ^{[1
]}

机构：

[1] NIMH,CLIN SCI LAB,ANALYT BIOCHEM SECT,BLDG 10,ROOM 3D40,BETHESDA,MD 20892

来源：

BRAIN RESEARCH | 1991年 / 546卷 / 01期

关键词：

KYNURENINE PATHWAY METABOLISM; CENTRAL NERVOUS SYSTEM; SYSTEMIC TISSUE; INDOLEAMINE-2,3-DIOXYGENASE; TRYPTOPHAN-2,3-DIOXYGENASE; CELLULAR IMMUNITY; GAMMA-INTERFERON;

D O I：

10.1016/0006-8993(91)91171-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chronic infections are associated with increased concentrations of the neuroactive kynurenine pathway metabolite, quinolinic acid (QUIN), in blood and cerebrospinal fluid. In the present study, repeated injections of gamma-interferon (5000 IU, every 3 days for 39 days) to C57BL6 mice were associated with persistent activation of indoleamine-2,3-dioxygenase (IDO), the first enzyme of the kynurenine pathway, in lung and brain, sustained increases in brain QUIN concentration and increases in plasma L-kynurenine and QUIN levels. Mice chronically treated with gamma-interferon offer an animal model to investigate the effects of sustained immune stimulation on kynurenine pathway metabolism.

引用

页码：151 / 154

页数：4

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