A MOLECULAR-MODEL FOR THE RETINOL BINDING-PROTEIN TRANSTHYRETIN COMPLEX

被引:12
作者
AQVIST, J
TAPIA, O
机构
[1] UNIV UPPSALA,DEPT MOLEC BIOL,S-75105 UPPSALA,SWEDEN
[2] UNIV UPPSALA,DEPT PHYS CHEM,S-75105 UPPSALA,SWEDEN
来源
JOURNAL OF MOLECULAR GRAPHICS | 1992年 / 10卷 / 02期
关键词
PROTEIN-PROTEIN INTERACTION; SURFACE FRACTALITY; RETINOL BINDING PROTEIN;
D O I
10.1016/0263-7855(92)80065-L
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A three-dimensional model for the complex between human serum retinol binding protein and transthyretin (formerly named prealbumin) is presented. The model was obtained by interactive rigid-body computer graphics docking and the characterization of the molecular surfaces in terms of fractal dimension. Available experimental data, as well as results from molecular dynamics calculations, support the proposed model.
引用
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页码:120 / 123
页数:4
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