LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR .1. TAXONOMY, FERMENTATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS

被引：12

作者：

NIHEI, Y

HASEGAWA, M

SUZUKI, K

YAMAMOTO, S

HANADA, M

FURUMAI, T

FUKAGAWA, Y

OKI, T

机构：

[1] Myers Squibb Research Institute, Iwate University, Tokyo, 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 06期

关键词：

D O I：

10.7164/antibiotics.46.900

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Lagunamycin. a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08 muM) without lipid peroxidation.

引用

页码：900 / 907

页数：8

共 14 条

[1]

Arai T., 1975, CULTURE MEDIA ACTINO

[2] CHEMICAL COMPOSITION OF CELL-WALL PREPARATIONS FROM STRAINS OF VARIOUS FORM-GENERA OF AEROBIC ACTINOMYCETES [J].

BECKER, B ;

LECHEVALIER, MP ;

LECHEVALIER, HA .

APPLIED MICROBIOLOGY, 1965, 13 (02) :236-+

[3] RAPID DIFFERENTIATION BETWEEN NOCARDIA + STREPTOMYCES BY PAPER CHROMATOGRAPHY OF WHOLE-CELL HYDROLYSATES [J].

BECKER, B ;

GORDON, RE ;

LECHEVALIER, HA ;

LECHEVALIER, MP .

APPLIED MICROBIOLOGY, 1964, 12 (05) :421-+

[4] A NOTE ON THE SEPARATION OF NATURAL MIXTURES OF BACTERIAL MENAQUINONES USING REVERSE PHASE THIN-LAYER CHROMATOGRAPHY [J].

COLLINS, MD ;

SHAH, HN ;

MINNIKIN, DE .

JOURNAL OF APPLIED BACTERIOLOGY, 1980, 48 (02) :277-282

[5] IDENTIFICATION OF THE INHIBITORY ACTIVITY OF CARBAZOMYCIN-B AND CARBAZOMYCIN-C AGAINST 5-LIPOXYGENASE, A NEW ACTIVITY FOR THESE COMPOUNDS [J].

HOOK, DJ ;

YACOBUCCI, JJ ;

OCONNOR, S ;

LEE, M ;

KERNS, E ;

KRISHNAN, B ;

MATSON, J ;

HESLER, G .

JOURNAL OF ANTIBIOTICS, 1990, 43 (10) :1347-1348

[6] LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR .2. STRUCTURAL STUDIES [J].

IMAE, K ;

NIHEI, Y ;

OKA, M ;

YAMASAKI, T ;

KONISHI, M ;

OKI, T .

JOURNAL OF ANTIBIOTICS, 1993, 46 (06) :1031-1033

[7]

LECHEVALIER MP, 1968, J LAB CLIN MED, V71, P934

[8] CHEMOTAXONOMY OF AEROBIC ACTINOMYCETES - PHOSPHOLIPID COMPOSITION [J].

LECHEVALIER, MP ;

DEBIEVRE, C ;

LECHEVALIER, H .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 1977, 5 (04) :249-260

[9] DIFFERENTIATION OF MYCOBACTERIUM, NOCARDIA, AND RELATED TAXA BY THIN-LAYER CHROMATOGRAPHIC ANALYSIS OF WHOLE ORGANISM METHANOLYSATES [J].

MINNIKIN, DE ;

ALSHAMAONY, L ;

GOODFELLOW, M .

JOURNAL OF GENERAL MICROBIOLOGY, 1975, 88 (MAY) :200-204

[10] EPOCARBAZOLIN-A AND EPOCARBAZOLIN-B, NOVEL 5-LIPOXYGENASE INHIBITORS - TAXONOMY, FERMENTATION, ISOLATION, STRUCTURES AND BIOLOGICAL-ACTIVITIES [J].

NIHEI, Y ;

YAMAMOTO, H ;

HASEGAWA, M ;

HANADA, M ;

FUKAGAWA, Y ;

OKI, T .

JOURNAL OF ANTIBIOTICS, 1993, 46 (01) :25-33

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