LAGUNAMYCIN, A NOVEL 5-LIPOXYGENASE INHIBITOR .1. TAXONOMY, FERMENTATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL CHARACTERISTICS

被引:12
作者
NIHEI, Y
HASEGAWA, M
SUZUKI, K
YAMAMOTO, S
HANADA, M
FURUMAI, T
FUKAGAWA, Y
OKI, T
机构
[1] Myers Squibb Research Institute, Iwate University, Tokyo, 153, 2-9-3 Shimo-meguro, Meguro-ku
关键词
D O I
10.7164/antibiotics.46.900
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Lagunamycin. a novel 5-lipoxygenase inhibitor, was isolated from the culture broth of Streptomyces sp. AA0310. This compound showed potent rat 5-lipoxygenase inhibitory activity (IC50 6.08 muM) without lipid peroxidation.
引用
收藏
页码:900 / 907
页数:8
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