DELTA-OPIOID RECEPTOR MEDIATES PHOSPHOLIPASE-C ACTIVATION VIA G(I) IN XENOPUS-OOCYTES

被引：56

作者：

MIYAMAE, T ^{[1
]}

FUKUSHIMA, N ^{[1
]}

MISU, Y ^{[1
]}

UEDA, H ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV,SCH MED,DEPT PHARMACOL,YOKOHAMA 236,JAPAN

来源：

FEBS LETTERS | 1993年 / 333卷 / 03期

关键词：

DELTA-OPIOID RECEPTOR; PERTUSSIS TOXIN; GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; PHOSPHOLIPASE C; XENOPUS OOCYTE;

D O I：

10.1016/0014-5793(93)80677-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cloned mouse delta-subtype opioid receptor (DOR 1) was expressed in Xenopus oocytes to study the signal transduction. Opioid delta-agonists evoked a calcium-dependent chloride current in oocytes injected with mRNA derived from DOR1, together with that from the alpha subunit of G(i)1. The delta-agonist-induced current was blocked by naltrindol, a delta-specific antagonist. The delta-agonist evoked no or very weak currents in oocytes with the alpha subunit of G(q) or G(o). These findings indicate the functional coupling between the opioid delta-receptor and phospholipase C through an activation of G(i).

引用

页码：311 / 314

页数：4

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