A MILD 2-STEP HYDROLYSIS OF GAMMA,DELTA-UNSATURATED ANILIDES

被引：11

作者：

METZ, P

机构：

[1] Organisch-Chemisches Institut der Universität Münster, D-4400 Münster

来源：

TETRAHEDRON | 1993年 / 49卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)80151-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Iodolactonization of gamma,delta-unsaturated anilides 2 in the presence of water and subsequent reduction of the resultant iodolactones 3 using zinc in acetic acid yield the carboxylic acids 4 without significant epimerization alpha to the carbonyl group. The diastereoselectivity inherent in iodolactonizations of anilides 2 resembles the kinetic stereoselection found for the corresponding transformations of related carboxylic acids.

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页码：6367 / 6374

页数：8

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