IGG AND IGM CONCENTRATION IN THE PROLAPSED HUMAN INTERVERTEBRAL DISC AND SCIATICA ETIOLOGY

被引:64
作者
SPILIOPOULOU, I
KOROVESSIS, P
KONSTANTINOU, D
DIMITRACOPOULOS, G
机构
[1] Departments of Microbiology, University of Patras Medical School, Patras
[2] Departments of Neurosurgery, University of Patras Medical School, Patras
[3] Department of Orthopaedic Surgery, General Hospital “Agios Andreas,”, Patras
关键词
NUCLEUS PULPOSUS; LOW BACK PAIN; SCIATICA; IMMUNOGLOBULINS;
D O I
10.1097/00007632-199406000-00003
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Design. A prospective study was conducted in patients who underwent surgeries for sciatica. The results were compared to those of control subjects. Objectives. This study expanded knowledge about the pathogenesis of back pain and sciatica in disc herniation. Methods. Nucleus pulposus, retrieved from 10 patients who underwent surgeries for sciatica caused by disc herniation and from 8 patients used as control subjects, was homogenized and together with serum and cerebrospinal fluid was examined for local production of IgG and IgM by rate nephelometry. Summary of the Background Data. Experimental data have shown an inflammatory reaction in the nucleus pulposus of animal models. Results and Conclusions. An increased ratio IgG(NP)/IgG(S) x 10(3) and IgM(NP)/IgM(S) x 10(3) was found in all patient samples, whereas only the IgM(NP)/IgM(S) X 10(3) ratio was significantly higher (P < 0.005) when compared with those of the control values. These findings may be secondary to an inflammatory reaction close to the nerve root and prolapsed nucleus pulposus. Therefore, they may contribute in some way to the inflammatory origin of sciatica.
引用
收藏
页码:1320 / 1323
页数:4
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