INCREASED LEVELS OF ANTIBODIES TO IFN-GAMMA IN HUMAN AND EXPERIMENTAL AFRICAN TRYPANOSOMIASIS

被引:17
作者
BONFANTI, C
CARUSO, A
BAKHIET, M
OLSSON, T
TURANO, A
KRISTENSSON, K
机构
[1] UNIV BRESCIA,INST MICROBIOL,BRESCIA,ITALY
[2] HUDDINGE HOSP,DEPT NEUROL,STOCKHOLM,SWEDEN
关键词
D O I
10.1111/j.1365-3083.1995.tb03532.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In African trypanosomiasis the occurrence of antibodies to interferon-gamma (IFN-gamma) was studied in both humans and experimental rats. Sera from patients infected with Trypanosoma brucei gambiense showed increased levels of antibodies to IFN-gamma as compared with controls from the same regions in Africa. In Sprague-Dawley rats infected with Trypanosoma brucei brucei an early appearance of IFN-gamma-producing spleen cells was observed, followed by an increase in levels of antibodies against IFN-gamma in the sera. Previously, IFN-gamma has been found to play a crucial role in trypanosome infections in rats by promoting proliferation of Trypanosoma brucei brucei. The appearance of antibodies to IFN-gamma in humans, as in rats, indicates that this cytokine is produced also in the human infection. Its parasitic growth-stimulating and pathophysiological effects on the organism may be reduced by the antibodies.
引用
收藏
页码:49 / 52
页数:4
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