CHEMICAL SYNTHESIS OF COENZYME A ANALOGS OF A MODIFIED CYSTEAMINE MOIETY

被引：11

作者：

SHIMIZU, M

NAGASE, O

HOSOKAWA, Y

TAGAWA, H

机构：

[1] Central Research Laboratory, Daiichi Seiyaku Co., Ltd., Edogawa-ku, Tokyo

来源：

TETRAHEDRON | 1968年 / 24卷 / 14期

关键词：

D O I：

10.1016/S0040-4020(01)88434-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Some coenzyme A analogs, such as α-methyl-(IVc), β-methyl-(IVd), and α-carboxy-coenzyme A (IVe), have been synthesized from the nitrile compound (Ib) and cysteamine derivatives (IIc-e) via the respective thiazoline intermediates (IIIc-e). Homo-coenzyme A (XII) has been synthesized by a combination of the methods of Moffatt and Khorana, for the formation of pyrophosphate, and Michelson, for 2′, 3′-cyclic phosphate fission. © 1968.

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页码：5241 / &

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