INVITRO METABOLIC ACTIVATION OF 1-PARA-CARBOXAMIDOPHENYL-3,-3-DIMETHYLTRIAZENE TO CYTOTOXIC PRODUCTS

被引：11

作者：

ABEL, G

CONNORS, TA

GIRALDI, T

机构：

[1] UNIV TRIESTE,IST FARMACOL,I-34100 TRIESTE,ITALY

[2] ROYAL CANC HOSP,INST CANC RES,CHESTER BEATTY RES INST,LONDON SW3 6JB,ENGLAND

来源：

CANCER LETTERS | 1977年 / 3卷 / 5-6期

关键词：

D O I：

10.1016/S0304-3835(77)96285-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：259 / 264

页数：6

共 11 条

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AUDETTE, RCS ;

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MERAI, K ;

ROSS, WCJ .

BIOCHEMICAL PHARMACOLOGY, 1973, 22 (15) :1855-1864

[2]

COMIS RL, 1976, CANCER TREAT REP, V60, P165

[3] TUMOR INHIBITORY TRIAZENES - STRUCTURAL REQUIREMENTS FOR AN ACTIVE METABOLITE [J].

CONNORS, TA ;

GODDARD, PM ;

MERAI, K ;

ROSS, WCJ ;

WILMAN, DEV .

BIOCHEMICAL PHARMACOLOGY, 1976, 25 (03) :241-246

[4] INVESTIGATION ON OXIDATIVE N-DEMETHYLATION OF ARYL TRIAZENES INVITRO [J].

GIRALDI, T ;

NISI, C ;

SAVA, G .

BIOCHEMICAL PHARMACOLOGY, 1975, 24 (19) :1793-1797

[5] OBSERVATIONS ON INVITRO OXIDATIVE N-DEMETHYLATION OF 4-(3,3-DIMETHYL-1-TRIAZENO)-IMIDAZOLE-5-CARBOXAMIDE (DIC, NSC-45388) [J].

GIRALDI, T ;

NISI, C ;

SAVA, G .

PHARMACOLOGICAL RESEARCH COMMUNICATIONS, 1976, 8 (01) :25-29

[6]

GIRALDI T, J MED CHEM

[7]

KOLAR GF, 1976, CHEMOTHERAPY, V8, P91

[8] PREPARATION AND ANTITUMOR ACTIVITY OF DERIVATIVES OF 1-PHENYL-3,3-DIMETHYLTRIAZENE [J].

LIN, Y ;

LOO, TL ;

VADLAMUDI, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (02) :201-+

[9]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[10]

VENDITTI JM, 1976, CANCER TREAT REP, V60, P135

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