INFLUENCE OF ULTRAVIOLET IRRADIATION ON SURFACE ACTIVITY OF PHENOTHIAZINE DRUGS

被引：7

作者：

FELMEISTER, A

SCHAUBMAN, R

机构：

[1] Rutgers, the State University, College of Pharmacy, Newark, New Jersey

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 10期

关键词：

Phenothiazines; surface activity–UV irradiation effect; Photosensitization; phenothiazines–surface activity relationship; Surface pressure; phenothiazines–UV irradiation effect;

D O I：

10.1002/jps.2600581015

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effect of drugs on the permeability of cell membranes has been related to their surface activity. It was of interest, therefore, to determine the influence of UV irradiation on the surface activity of a series of potential photosensitizers. Solutions of five phenothiazine drugs (1 × 10−4 M) were prepared in an acetate buffer. The solutions were exposed to UV irradiation and the surface pressure determined at fixed intervals by the Wilhelmy plate method. Chlorpromazine and prochlorperazine showed an increase in surface pressure during irradiation. Promazine showed no surface activity either before or after irradiation. Triflupromazine and trifluoperazine exhibited a decrease in surface pressure during irradiation. Both chlorpromazine and prochlorperazine have been clearly established as photosensitizers. The other drugs studied, except for a few isolated instances, have not been reported as photosensitizers. Thus, there appears to be a relationship between an increase in surface activity induced by irradiating a drug and the drug's in vivo photosensitizing properties. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1232 / +

页数：1

共 7 条

[1]

ADAMSON AW, 1967, PHYSICAL CHEMISTRY S, P26

[2]

BURCKHARDT W, 1957, Schweiz Med Wochenschr, V87, P954

[3] PHOTOINDUCED INTERACTIONS OF PHENOTHIAZINE DRUGS WITH A LECITHIN MONOMOLECULAR FILM [J].