AGE-DEPENDENT INCREASE IN THE FORMATION OF PROSTAGLANDIN-I2 BY INTACT AND HOMOGENIZED AORTAE FROM THE DEVELOPING SPONTANEOUSLY HYPERTENSIVE RAT

被引:41
作者
PACEASCIAK, CR
CARRARA, MC
机构
[1] Research Institute, The Hospital for Sick Children, Toronto, Ont. M5G 1X8
关键词
(Rat); Aorta; Hypertension; Prostaglandin I[!sub]2[!/sub;
D O I
10.1016/0005-2760(79)90097-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The prostaglandin I, biosynthetic capacity of aortae from spontaneously hypertensive rats of various ages (1, 2, 3, 4, and 5 months) was investigated. An age-dependent increase in enzyme activity was observed reaching maximum by three months of age which correlated well with the age- related increase in the systolic blood pressure. These results support our notion that the enhanced aortic synthesis of the potent vasodepressor prostaglandin 12 by the spontaneously hypertensive rat likely represents an adaptive mechanism for the attenuation of the sustained elevation in blood pressure in this animal model. © 1979.
引用
收藏
页码:177 / 181
页数:5
相关论文
共 5 条
[1]   COMPARISON OF VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6-OXO-PROSTAGLANDIN F-1-ALPHA WITH THOSE OF PROSTAGLANDIN-E2 IN RATS AND RABBITS [J].
ARMSTRONG, JM ;
LATTIMER, N ;
MONCADA, S ;
VANE, JR .
BRITISH JOURNAL OF PHARMACOLOGY, 1978, 62 (01) :125-130
[2]  
BOLGER PM, 1978, NATURE, V271, P467
[3]   PROSTAGLANDIN-I2 HAS MORE POTENT HYPOTENSIVE PROPERTIES THAN PROSTAGLANDIN-E2 IN NORMAL AND SPONTANEOUSLY HYPERTENSIVE RAT [J].
PACEASCIAK, CR ;
CARRARA, MC ;
NICOLAOU, KC .
PROSTAGLANDINS, 1978, 15 (06) :999-1003
[4]   ENHANCED FORMATION OF PGI2, A POTENT HYPOTENSIVE SUBSTANCE, BY AORTIC RINGS AND HOMOGENATES OF SPONTANEOUSLY HYPERTENSIVE RAT [J].
PACEASCIAK, CR ;
CARRARA, MC ;
RANGARAJ, G ;
NICOLAOU, KC .
PROSTAGLANDINS, 1978, 15 (06) :1005-1012
[5]  
PACEASCIAK CR, 1978, PROSTAG OTH LIPID M, V15, P704