AGE-DEPENDENT INCREASE IN THE FORMATION OF PROSTAGLANDIN-I2 BY INTACT AND HOMOGENIZED AORTAE FROM THE DEVELOPING SPONTANEOUSLY HYPERTENSIVE RAT

被引：41

作者：

PACEASCIAK, CR

CARRARA, MC

机构：

[1] Research Institute, The Hospital for Sick Children, Toronto, Ont. M5G 1X8

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 574卷 / 01期

关键词：

(Rat); Aorta; Hypertension; Prostaglandin I[!sub]2[!/sub;

D O I：

10.1016/0005-2760(79)90097-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The prostaglandin I, biosynthetic capacity of aortae from spontaneously hypertensive rats of various ages (1, 2, 3, 4, and 5 months) was investigated. An age-dependent increase in enzyme activity was observed reaching maximum by three months of age which correlated well with the age- related increase in the systolic blood pressure. These results support our notion that the enhanced aortic synthesis of the potent vasodepressor prostaglandin 12 by the spontaneously hypertensive rat likely represents an adaptive mechanism for the attenuation of the sustained elevation in blood pressure in this animal model. © 1979.

引用

页码：177 / 181

页数：5

共 5 条

[1] COMPARISON OF VASODEPRESSOR EFFECTS OF PROSTACYCLIN AND 6-OXO-PROSTAGLANDIN F-1-ALPHA WITH THOSE OF PROSTAGLANDIN-E2 IN RATS AND RABBITS [J].