REACTIONS OF IRON(II) NUCLEOTIDE COMPLEXES WITH HYDROGEN-PEROXIDE

被引：79

作者：

RUSH, JD

MASKOS, Z

KOPPENOL, WH

机构：

[1] LOUISIANA STATE UNIV,INST BIODYNAM,BATON ROUGE,LA 70803

[2] LOUISIANA STATE UNIV,DEPT CHEM,BATON ROUGE,LA 70803

[3] LOUISIANA STATE UNIV,DEPT BIOCHEM,BATON ROUGE,LA 70803

来源：

FEBS LETTERS | 1990年 / 261卷 / 01期

关键词：

Adenosine triphosphate; Fenton reaction; Ferrous; Ferryl intermediate; Hydrogen peroxide; Nucleotide; Pyrophoshate;

D O I：

10.1016/0014-5793(90)80651-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rate constants for the reactions of hydrogen peroxide with ferrous complexes of ATP, ADP, UTP, citrate and pyrophosphate were measured at pH 7.2. These ligands are potential chelators of iron(II) in the low-molecular weight iron pool that may catalyze oxidative degradation of tissues. The second-order rate constants range from 5.5 × 103 M-1s-1 (UTP) to 1 × 105 M-1s-1 (pyrophosphate) at pH 7.2. The kinetic dependences of the ATP reaction are consistent with a mechanism involving a 'ferryl' (FeIV) transient which decays to the hydroxyl radical and ferric ATP. © 1990.

引用

页码：121 / 123

页数：3

共 19 条

[1]

BAKKEREN DL, 1989, INT J BIOCHEM, V17, P791

[2] CRITICAL-REVIEW OF RATE CONSTANTS FOR REACTIONS OF HYDRATED ELECTRONS, HYDROGEN-ATOMS AND HYDROXYL RADICALS (.OH/.O-) IN AQUEOUS-SOLUTION [J].