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GROWTH OF FRANCISELLA-SPP IN RODENT MACROPHAGES

被引：183
作者：
ANTHONY, LSD
BURKE, RD
NANO, FE
机构：
[1] UNIV VICTORIA,DEPT BIOL,VICTORIA V8W 3P6,BC,CANADA
[2] CANADIAN BACTERIAL DIS NETWORK,VICTORIA V8W 3P6,BC,CANADA
来源：
INFECTION AND IMMUNITY | 1991年 / 59卷 / 09期
关键词：
D O I：
10.1128/IAI.59.9.3291-3296.1991
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We examined the nature of the interactions between the facultative intracellular pathogens Francisella tularensis and F. novicida and rodent macrophages. Growth of F. tularensis LVS was observed in macrophage monolayers from mice, guinea pigs, or rats. In contrast, F. novicida grew in macrophages from mice and guinea pigs but not in macrophages from rats. Transmission electron microscopy studies indicated that both Francisella species survive within macrophage phagosomes that are unfused with lysosomes.
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页码：3291 / 3296
页数：6
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