OXIDATION OF NATURAL TARGETS BY DIOXIRANES .2. DIRECT HYDROXYLATION AT THE SIDE-CHAIN C-25 OF CHOLESTANE DERIVATIVES AND OF VITAMIN-D3 WINDAUS-GRUNDMANN KETONE

被引：74

作者：

BOVICELLI, P

LUPATTELLI, P

MINCIONE, E

PRENCIPE, T

CURCI, R

机构：

[1] UNIV BARI,DEPT CHEM,CTR MISO,CNR,V AMENDOLA 173,I-70126 BARI,ITALY

[2] UNIV ROME LA SAPIENZA,DEPT CHEM,CTR CSON,CNR,I-00185 ROME,ITALY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1992年 / 57卷 / 19期

关键词：

D O I：

10.1021/jo00045a004

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct, high-yield oxyfunctionalization of the side-chain C-25 of 5-alpha-cholestan-3-one, 3-beta-acetoxy-5-alpha-cholestane, and 5-alpha,6-beta-Br2-3-beta-acetoxycholestane as well as of the vitamin D3-derived Windaus-Grundmann ketone has been achieved under mild conditions employing either dimethyldioxirane or its trifluoromethyl analogue.

引用

页码：5052 / 5054

页数：3

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