EFFECTS OF HPA HORMONES ON ADAPTED LYMPHOCYTE RESPONSIVENESS TO REPEATED STRESS

被引:14
作者
SANDI, C [1 ]
CAMBRONERO, JC [1 ]
BORRELL, J [1 ]
GUAZA, C [1 ]
机构
[1] CSIC,CAJAL INST,PSYCHOBIOL RES GRP,DR ARCE 37,E-28002 MADRID,SPAIN
关键词
NEUROIMMUNOMODULATION; STRESS; RECOVERY; HPA HORMONES; LYMPHOCYTE PROLIFERATION; RAT;
D O I
10.1016/0361-9230(92)90106-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Acute stress-induced immune alterations can result in adapted function with prolonged exposure to the same stressor. The present study was designed to evaluate the possible role of the hypothalamic-pituitary-adrenocortical (HPA) axis on the adaptation of spleen lymphocyte responsiveness to repeated stress. For this purpose, we selected a stressful protocol (aversive auditory stimulation) that induced an initial suppression (1 day), followed by a return to control values with repeated application (4 days), of mitogen-induced lymphocyte proliferation. Because rats exposed to 4 days of noise sessions show enhanced adrenocorticotropin (ACTH) and corticosterone levels, we tested the possibility that adaptation of lymphoproliferation by repeated stress was due to a desensitization of splenic lymphocytes to stress-released HPA hormones. The results showed that corticotropin-releasing factor (10(-9) M) and corticosterone (5 X 10(-8) and 10(-7) M), as well as dexamethasone (10(-8), 5 X 10(-8), and 10(-7) M), significantly suppressed lymphoproliferation from both control and stressed rats in a similar way. ACTH (10(-9) and 5 X 10(-9) M) did not significantly influence ConcanavalinA-stimulated spleen lymphocytes. These data indicate that adaptation of lymphocyte proliferation by repeated noise stress occurs without accompanying alterations in lymphocyte responsiveness to HPA hormones.
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页码:581 / 585
页数:5
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