EARLY POSTOPERATIVE 5-FLUOROURACIL DOES NOT AFFECT THE HEALING OF EXPERIMENTAL INTESTINAL ANASTOMOSES

被引：30

作者：

DEWAARD, JWD

WOBBES, T

HENDRIKS, T

机构：

[1] Department of General Surgery, University Hospital, Nijmegen, 6500 HB, St. Radboud

来源：

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE | 1993年 / 8卷 / 03期

关键词：

D O I：

10.1007/BF00341194

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

5-Fluorouracil (5-FU) remains the mainstay for systemic treatment of colorectal cancer. In view of the increasing interest in peri-operative administration of antineoplastic agents, we have investigated the effects of early postoperative 5-FU on the healing of intestinal anastomoses in the rat. Animals underwent resection and anastomosis of both ileum and colon and 5-FU (20 mg/kg body weight) was given, either intravenously or intraperitoneally, on the day of surgery and the two subsequent days. Healing was assessed three and seven days after operation. Administration of 5-FU led to a reduced white blood cell count. However, anastomotic strength was not significantly reduced at either time point and anastomotic hydroxyproline content was not significantly affected. We suggest that limited use of 5-FU during or immediately after operation does not necessarily affect early anastomotic healing in the intestine.

引用

页码：175 / 178

页数：4

共 26 条

[1]

Grem J.L., Current treatments approaches in colorectal cancer, Semin Oncol, 18, pp. 17-26, (1991)

[2]

Mayer R.J., Systematic therapy for colorectal cancer: an overview, Semin Oncol, 18, pp. 62-66, (1991)

[3]

Falcone R.E., Nappi J.F., Chemotherapy and wound healing, Surg Clin N Am, 64, pp. 779-794, (1984)

[4]

de Roy van Zuidewijn D.B.W., Wobbes, Hendriks, Klompmakers A.A., de Boer H.H.M., The effect of antineoplastic agents on the healing of small intestinal anastomoses in the rat, Cancer, 58, pp. 62-66, (1986)

[5]

De Roy van Zuidewijn D.B.W., Wobbes, Hendriks, de Boer H.H.M., Effects of intraperitoneal cytostatics on the healing of experimental intestinal anastomoses, Br J Cancer, 63, pp. 937-941, (1991)

[6]

Martens M.F.W.C., Hendriks, Wobbes T., De Pont J.J.H.H.M., Intraperitoneal cytostatics impair early post-operative collagen synthesis in experimental intestinal anastomoses, Br J Cancer, 65, pp. 649-654, (1992)

[7]

Harris D.T., Mastrangelo M.J., Theory and application of early systemic therapy, Semin Oncol, 18, pp. 493-503, (1991)

[8]

Goldie J.H., Coldman A.J., The genetic origin of drug resistance in neoplasms: implications for systematic therapy, Cancer Res, 44, pp. 3643-3653, (1984)

[9]

Gunduz N., Fisher B.V., Saffer E.A., Effect of surgical removal on the growth and kinetics of residual tumor, Canxer Res, 39, pp. 3861-3865, (1979)

[10]

Wils J.A., High dose Fluorouracil: A new perspective in the treatment of colorectal cancer, Semin Oncol, 19, pp. 126-130, (1992)

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