PROGESTERONE THERAPY IN WOMEN WITH COMPLEX PARTIAL AND SECONDARY GENERALIZED SEIZURES

被引：154

作者：

HERZOG, AG ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT NEUROL,BOSTON,MA 02115

来源：

NEUROLOGY | 1995年 / 45卷 / 09期

关键词：

D O I：

10.1212/WNL.45.9.1660

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This open trial assessed the effects of adjunctive progesterone therapy on seizure frequency in 25 women with catamenial exacerbation of complex partial (CPS) and secondary generalized motor (SGMS) seizures. Progesterone was well tolerated by 23 of the 25 women and had readily reversible dose-related side effects of asthenia and emotional depression in two. Eighteen women (72%) experienced a decline in seizure frequency during a 3-month treatment period compared with the 3 months prior to therapy (p < 0.01). Average daily CPS frequency declined by 54% (p < 0.01), SGMS by 58% (p < 0.02).

引用

页码：1660 / 1662

页数：3

共 16 条

[1]

BACKSTROM T, 1976, ACTA NEUROL SCAND, V54, P321

[2] REPRODUCTIVE ENDOCRINE DISORDERS IN WOMEN WITH PRIMARY GENERALIZED EPILEPSY [J].