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A 3-DEAZAURACIL-RESISTANT MUTANT OF BACILLUS-SUBTILIS WITH INCREASED PRODUCTION OF CYTIDINE

被引：13
作者：
ASAHI, S
TSUNEMI, Y
IZAWA, M
DOI, M
机构：
[1] Fermentation Center, Technology Development Laboratories, Takeda Chemical Industries Ltd., Yodogawa-ku
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1995年 / 59卷 / 05期
关键词：
D O I：
10.1271/bbb.59.915
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bacillus subtilis No, 344 is a cytidine-producing mutant strain derived from wild type strain No. 122, When 3-deazauracil-resistant mutants were derived from strain No, 344, some of the mutants had higher productivities of cytidine. Among them, strain No, 428 accumulated 14.2 mg/ml cytidine in the culture. Cytidine 5'-triphosphate (CTP) synthetase from strain No, 428 changed to be free from feedback inhibition by CTP, compared with the enzyme from strain No, 344.
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页码：915 / 916
页数：2
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