SEQUENTIAL POLYPEPTIDES - SYNTHESIS OF N-PROTECTED, C-ACTIVATED PEPTIDES FROM C-TERMINAL RESIDUES OF AMINO ACIDS

A modified mixed anhydride method is reported from which satisfactory yields are obtained by the coupling of N‐carbobenzoxy amino acids with di‐ and tripeptide pentachlorophenyl active ester hydrochlorides. This method provides a convenient approach which limits the degree of racemization during the synthesis of N‐protected, C‐activated peptide units used for the preparation of sequential polypeptides. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company