CHARACTERIZATION OF MOUSE ALLERGENS

被引：51

作者：

SIRAGANIAN, RP

SANDBERG, AL

机构：

[1] Laboratory of Microbiology and Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1979年 / 63卷 / 06期

关键词：

D O I：

10.1016/0091-6749(79)90219-7

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The major allergens present in mouse skin, serum, and urine have been identified. Skin extracts, serum, and urine were chromatographed, and the activities of the fractions were monitored by histamine release from the leukocytes of individuals sensitive to mice. Fractionation of skin extracts revealed two major allergens. The large allergen has a molecular weight of ~67,000 daltons and by biochemical and immunochemical criteria appears to be identical to mouse albumin. The smaller molecular weight allergen is ~17,000 daltons. The same two allergens are also found in mouse serum and mouse urine. Histamine release by leukocytes of individuals allergic to mice demonstrated that some individuals react predominantly to the large allergen, some to the small allergen, and one group of patients reacts to both allergens. © 1979.

引用

页码：435 / 442

页数：8

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