ENHANCEMENT OF HUMAN HERPESVIRUS-6 REPLICATION IN ADULT HUMAN-LYMPHOCYTES BY MONOCLONAL-ANTIBODY TO CD3

被引：14

作者：

KIKUTA, H

LU, H

TOMIZAWA, K

MATSUMOTO, S

机构：

[1] Department of Pediatrics, Hokkaido University School of Medicine, sapporo

来源：

JOURNAL OF INFECTIOUS DISEASES | 1990年 / 161卷 / 06期

关键词：

D O I：

10.1093/infdis/161.6.1085

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of monoclonal antibody to CD3 on human herpesvirus 6 (HHV-6) replication was assessed in adult peripheral blood mononuclear cells (PBMC) and in cord blood mononuclear cells (CBMC) by anticomplement immunofluorescence and Southern blot hybridization. Infection ofCBMC by HHV-6 was productive; however, little or no infection was observed with PBMC from adults exposed to the virus even if stimulated by phytohemagglutinin. Monoclonal antibody to CD3 strongly enhanced HHV-6 replicative cycles in PBMC from adults. © 1990, University of Chicago. All rights reserved.

引用

页码：1085 / 1087

页数：3

共 7 条

[1] POLYMORPHISM OF HUMAN HERPESVIRUS-6 DNA FROM 5 JAPANESE PATIENTS WITH EXANTHEM SUBITUM [J].