PANCREATIC SECRETORY TRYPSIN-INHIBITOR (PSTI) ISOLATED FROM PIG INTESTINE - INFLUENCE ON INSULIN AND SOMATOSTATIN RELEASE

被引：6

作者：

AGERBERTH, B

OSTENSON, CG

EFENDIC, S

JORNVALL, H

机构：

[1] KAROLINSKA INST,DEPT CHEM 1,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA INST,DEPT ENDOCRINOL,S-10401 STOCKHOLM 60,SWEDEN

来源：

FEBS LETTERS | 1991年 / 281卷 / 1-2期

关键词：

PANCREATIC SECRETORY TRYPSIN INHIBITOR; PIG INTESTINE; TRYPSIN INHIBITOR; PERFUSED RAT PANCREAS;

D O I：

10.1016/0014-5793(91)80399-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Upon investigation of pig intestinal peptides for effects on the release of endocrine hormones from the isolated perfused rat pancreas, we reported earlier that glucose-stimulated insulin release was inhibited by PEC-60, a peptide with marked sequence similarity to PSTI (pancreatic secretory trypsin inhibitor). Continuing this study we found a polypeptide, which inhibited glucose-induced insulin release but enhanced glucose-induced somatostatin secretion. Determination of the amino acid sequence of this polypeptide revealed that it is identical to that of PSTI. Thus, PSTI modulates islet hormone release.

引用

页码：227 / 230

页数：4

共 22 条

[1] ISOLATION AND CHARACTERIZATION OF A 60-RESIDUE INTESTINAL PEPTIDE STRUCTURALLY RELATED TO THE PANCREATIC SECRETORY TYPE OF TRYPSIN-INHIBITOR - INFLUENCE ON INSULIN-SECRETION [J].