PLASMA CYCLIC-AMP RESPONSE TO PARATHYROID-HORMONE IN TURNERS SYNDROME AND ALBRIGHT HEREDITARY OSTEODYSTROPHY

Purified bovine parathyroid hormone (BPTH) given by injection to five patients with Turner's syndrome, and seven healthy volunteers produced a significant rise in plasma cyclic AMP reaching a maximum within 10 min. In a pseudohypoparathyroid patient there was no increase. Urinary excretion of cyclic AMP exceeded the normal in three out of four patients with Turner's syndrome. Thus, if there is a relationship between Turner's syndrome and Albright's osteodystrophy it is with the incomplete form known as pseudo‐pseudohypoparathyroidism. Copyright © 1979, Wiley Blackwell. All rights reserved