DOWN-REGULATION OF PROSTAGLANDIN-E2 RECEPTORS IN REGENERATING RAT-LIVER AND ITS PHYSIOLOGICAL SIGNIFICANCE

被引：17

作者：

HASHIMOTO, N

WATANABE, T

IKEDA, Y

TODA, G

YAMADA, H

YOSHIKAWA, Y

MITSUI, H

KUROKAWA, K

机构：

[1] First Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, 113

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 176卷 / 01期

关键词：

D O I：

10.1016/0006-291X(91)90913-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The properties of prostaglandin(PG) E2 receptors in regenerating liver were studied using rat hepatocytes in primary culture. The control cells possessed stereo-specific PGE2 receptors with Bmax and Kd values, at 4°C, of 526 fmol/mg protein and 6.5 nM respectively. In cells from regenerating liver after 70% hepatectomy, Bmax was reduced to 42-43% that of the controls; Kd did not change. Administration of indomethacin before surgery prevented Bmax reduction. These results indicate that PGE2, produced during the regeneration process, evoked cellular events and regulated the density of its receptors. © 1991.

引用

页码：226 / 232

页数：7

共 18 条

[1] STIMULATION OF DNA-SYNTHESIS AND MITOSIS OF HEPATOCYTES IN PRIMARY CULTURES OF NEONATAL RAT-LIVER BY ARACHIDONIC-ACID AND PROSTAGLANDINS [J].