PRESSOR DOSES OF ANGIOTENSIN-II INCREASE INSULIN-MEDIATED GLUCOSE-UPTAKE IN NORMOTENSIVE MEN

被引:61
作者
TOWNSEND, RR
DIPETTE, DJ
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 03期
关键词
EUGLYCEMIC CLAMP; INSULIN SENSITIVITY; HEPATIC GLUCOSE OUTPUT; GLUCOSE OXIDATION;
D O I
10.1152/ajpendo.1993.265.3.E362
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The effect of pressor doses of angiotensin II infused intravenously on insulin-mediated glucose uptake was determined in normotensive men. A 3-h hyperinsulinemic euglycemic clamp was employed in 14 normotensive subjects to determine insulin-mediated glucose uptake with or without an infusion of angiotensin II (approximately 15 ng.kg-1.min-1), which increased blood pressure by 20/15 mmHg (systolic/diastolic). Addition of angiotensin II increased whole body glucose uptake by 15% (9.2 +/- 0.5 vs. 10.8 +/- 0.8 mg.kg-1.min-1; P= 0.011), and glucose oxidation (determined by indirect calorimetry) by 25% (4.0 +/- 0.3 vs. 4.9 +/- 0.4 mg.kg-1.min-1; P < 0.05) over insulin alone. There was no significant increase in hepatic glucose output during angiotensin II infusion (2.2 +/- 0.1 vs. 2.4 +/- 0.1 mg.kg-1.min-1; P = NS). We conclude that angiotensin II in pressor doses increases insulin-mediated glucose disposal and oxidation. The mechanism for this may involve a redirection of blood flow into skeletal muscle during angiotensin II infusion or a direct biochemical action of angiotensin II. Although performed in lean normotensive subjects, these results cast doubt on a significant role for angiotensin II in the insulin resistance associated with essential hypertension.
引用
收藏
页码:E362 / E366
页数:5
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