INHIBITION OF PHAGOCYTOSIS OF HUMAN MACROPHAGES INDUCED BY AIRBORNE-PARTICULATES

被引：9

作者：

HADNAGY, W ^{[1
]}

SEEMAYER, NH ^{[1
]}

机构：

[1] UNIV DUSSELDORF, MED INST ENVIRONM HYG, D-40223 DUSSELDORF, GERMANY

来源：

TOXICOLOGY LETTERS | 1994年 / 72卷 / 1-3期

关键词：

AIRBORNE PARTICULATES; HUMAN MACROPHAGES; PHAGOCYTOSIS; CELL VIABILITY;

D O I：

10.1016/0378-4274(94)90006-X

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Human monocyte-derived macrophages isolated from peripheral blood were treated with different extracts of airborne particulates collected in the highly industrialized Rhine-Ruhr area. AH tested extracts showed a substantial impairment of phagocytosis by inhibition of phagocytic activity as well as phagocytic capacity, while cell viability was rather well maintained. Significant reduction of phagocytosis already appeared at a concentration equivalent to extracted particulates from 3.8 m(3) air. Having properties of alveolar macrophages, human monocyte-derived macrophage cultures may offer a reliable in vitro model for assessment of pulmonary toxicity by respirable pollutants.

引用

页码：23 / 31

页数：9

共 15 条

[1]

BECK B, 1988, ANN OCCUP HYG, V32, P257

[2]

DANNENBERG, 1977, J RETICULOENDOTHEL S, V22, P273

[3]

DEHNEN W, 1977, CANCER LETT, V4, P5

[4]

GULYAS H, 1990, ENV HYGIENE, V2, P191

[5] COMPARATIVE-STUDY OF SISTER-CHROMATID EXCHANGES AND CHROMOSOMAL-ABERRATIONS INDUCED BY AIRBORNE-PARTICULATES FROM AN URBAN AND A HIGHLY INDUSTRIALIZED LOCATION IN HUMAN-LYMPHOCYTE CULTURES [J].

HADNAGY, W ;

SEEMAYER, NH ;

TOMINGAS, R ;

IVANFY, K .

MUTATION RESEARCH, 1989, 225 (1-2) :27-32

[6] HUMAN MONOCYTE-DERIVED MACROPHAGE CULTURES - AN ALTERNATIVE TEST SYSTEM FOR THE DETECTION OF PULMONARY TOXICITY INDUCED BY INHALED PARTICULATE POLLUTANTS [J].

HADNAGY, W ;

SEEMAYER, NH ;

HAPPEL, A ;

KIELL, A .

TOXICOLOGY IN VITRO, 1993, 7 (04) :365-&

[7]

HADNAGY W, 1993, INN PRESS ANN OCCUPH

[8] INHALABLE PARTICLES AND PULMONARY HOST DEFENSE - INVIVO AND INVITRO EFFECTS OF AMBIENT AIR AND COMBUSTION PARTICLES [J].

HATCH, GE ;

BOYKIN, E ;

GRAHAM, JA ;

LEWTAS, J ;

POTT, F ;

LOUD, K ;

MUMFORD, JL .

ENVIRONMENTAL RESEARCH, 1985, 36 (01) :67-80

[9]

KIELL A, 1993, ILSI MONOGR, P323

[10]

LIU WK, 1987, J TEST EVAL, V15, P3

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