THE STRUCTURE OF THE HUMAN STEROL CARRIER PROTEIN-X STEROL CARRIER PROTEIN-2 GENE (SCP2)

Sterol carrier protein X (SCPx) is a 58-kDa protein that is localized to peroxisomes, The amino acid sequence of the protein suggests that SCPx may function as a thiolase, The gene encoding SCPx also codes for a 15.3-kDa protein called sterol carrier protein 2 (SCP2). Here we report the structure of this gene (SCPS), which spans approximately 80 kb and consists of 16 exons and 15 introns, Multiple transcription start sites were identified. The 5' flanking region has characteristics of other peroxisomal protein promoters, which include the absence of a TATA box and a G+C-enriched region containing several reverse GC boxes. (C) 1994 Academic Press, Inc.