STRATEGIES FOR MAPPING AND IMITATING VIRAL B-CELL EPITOPES

被引：13

作者：

CASON, J

机构：

[1] The Richard Dimbleby Laboratory for Cancer Virology, The Rayne Institute, St Thomas' Hospital, London, SE1 7EH, Lambeth Palace Road

来源：

JOURNAL OF VIROLOGICAL METHODS | 1994年 / 49卷 / 02期

关键词：

VIRUS; EPITOPE MAPPING; ANTIBODY;

D O I：

10.1016/0166-0934(94)90045-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Identification of viral B-cell epitopes is of importance in the selection of peptides for inclusion into subunit vaccines, the development of virus-specific serological tests and understanding the interaction of antibodies with viruses at a molecular level. B-cell epitopes can often be determined unequivocally by X-ray analyses of antibody-antigen complexes. This technique is, however, time-consuming and alternative strategies have now been developed for identifying epitopes. This article provides an overview of approaches which are currently available for mapping and imitating B-cell epitopes.

引用

页码：209 / 219

页数：11

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