DETERMINANTS OF ARTERIAL STIFFNESS IN CHINESE MIGRANTS TO AUSTRALIA

The determinants of arterial properties in Chinese migrants to Australia were evaluated. Fifty-eight migrants had recently arrived while 25 were long term residents. All were apparently free of cardiovascular disease. In addition to ultrasound determination of the stiffness of the thoracic aorta, measurements were also made of pulse wave velocities in the trunk and limbs. Factors investigated as potential determinants of arterial properties included age, sex, blood pressure, plasma lipids, urinary electrolyte excretion and duration of residence in Australia. Aortic stiffness and aortic pulse wave velocity (PWV) were both strongly and positively related to age and also correlated well with one another. The various arterial indices were entered in a series of multiple regression analyses. Aortic PWV (PWVAF), PWV from the femoral to dorsalis pedis artery (PWVFD) and the aortic elastic modulus E(p) were all dependent on age and mean arterial pressure. E(p) was additionally dependent on sodium excretion (negatively), PWVAF on LDL cholesterol (negatively) and migrant status and PWVFD on sex and potassium excretion (negatively). PWV in the arm (PWVBR) was only dependent on sex. Regional aortic stiffness E(p) and PWVAF were significantly higher in the established compared with the recent migrants. Dietary differences were evident between the two migration groups, with recent migrants eating significantly more rice meals, but there were no differences in plasma total or HDL cholesterol or triglyceride concentrations. Determinants of the stiffness of the arterial circulation in disease free Chinese subjects change considerably from proximal to distal sites, with age, blood pressure and cholesterol effects being most pronounced proximally and sex and urinary potassium excretion distally. Increasing duration of Australian residence appears to be accompanied by an increase in proximal arterial stiffness.