CLONING AND SEQUENCING OF HUMAN LH HCG RECEPTOR CDNA

被引：240

作者：

MINEGISH, T ^{[1
]}

NAKAMURA, K ^{[1
]}

TAKAKURA, Y ^{[1
]}

MIYAMOTO, K ^{[1
]}

HASEGAWA, Y ^{[1
]}

IBUKI, Y ^{[1
]}

IGARASHI, M ^{[1
]}

机构：

[1] NATL CARDIOVASC CTR,RES INST,SUITA,OSAKA 565,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 172卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91552-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and sequenced a cDNA encoding the human luteinizing hormone - choriogonadotropin ( LH hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87 % identical overall with the previously cloned rat and porcine LH hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively). © 1990.

引用

页码：1049 / 1054

页数：6

共 13 条

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